Ammonium Ylide Mediated Cyclization Reactions
نویسندگان
چکیده
منابع مشابه
Towards a General Understanding of Carbonyl‐Stabilised Ammonium Ylide‐Mediated Epoxidation Reactions
The key factors for carbonyl-stabilised ammonium ylide-mediated epoxidation reactions were systematically investigated by experimental and computational means and the hereby obtained energy profiles provide explanations for the observed experimental results. In addition, we were able to identify the first tertiary amine-based chiral auxiliary that allows for high enantioselectivities and high y...
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ABSTRACT Detailed DFT studies provide an in-depth mechanistic understanding for the use of chiral amide-based ammonium ylides in epoxidation reactions. It is shown that the used chiral auxiliary efficiently shields one face of the ylide, which thus results in an extraordinarily high stereoselectivity giving only one trans-isomer with perfect control of the absolute configuration. GRAPHICAL AB...
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ژورنال
عنوان ژورنال: Asian Journal of Organic Chemistry
سال: 2018
ISSN: 2193-5807,2193-5815
DOI: 10.1002/ajoc.201800091